San Francisco surrendered 291 yards and 41 points during the Week 15 loss to Dallas and plays Arizona on Saturday.

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San Francisco gave up 193 yards and nine offensive points during the Week 14 loss to Washington and play Dallas on Sunday.

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The 49ers gave up 449 yards and 34 points during the Week 13 loss to the Bills and play Washington on Sunday.

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The 49ers gave up 308 yards and 13 offensive points during the Week 12 win over the Rams and play the Bills on Monday.

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The 49ers come out of their bye week ranked seventh in total defense (315.9 YPG) and 11th in scoring (23.4 PPG) as they head into Sunday's game against the Rams.

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The 49ers gave up 405 yards and 34 points during the Week 9 loss to the Packers and play the Saints on Sunday.

Analysis: QB Aaron Rodgers had a stellar day and averaged 9.8 yards per attempt, while WR Davante Adams had 10 catches for 173 yards and a score. Unfortunately for San Francisco, things don't get much better in Week 10 as it heads to New Orleans, which just put down a beatdown on Tampa Bay's strong defense. The 49ers D/ST is once again a poor option this week while going up against QB Drew Brees and a Saints offense that excels in ball security (seven giveaways) and pass protection (10 sacks allowed).

The 49ers gave up 350 yards and 37 points during the Week 8 loss to the Seahawks and play the Packers on Thursday.

Analysis: San Fran had zero answer for WR DK Metcalf, as he had 12 receptions for 161 yards and two touchdowns. WR Davante Adams presents similar matchup problems in Week 9, as he has 20 catches for 249 yards and five touchdowns in the past two games. The Packers have only three giveaways and nine sacks allowed through seven games, so there may not be significant playmaking chances. The 49ers D/ST faces a tough matchup for the second consecutive week.

The 49ers allowed 241 yards and six points during the Week 7 win over the Patriots and play the Seahawks on Sunday.

Analysis: San Francisco entered the contest with only six takeaways all season, but it had four interceptions off Cam Newton and Jarrett Stidham while holding New England to a pair of field goals. Russell Wilson is coming off a similar performance against the Cardinals as he threw three picks, but a repeat performance shouldn't be expected. The Seahawks has the top offense in the league in scoring (33.8 PPG) and yardage (425.2 YPG) and has yet to score fewer than 27 points in a game this season. The…read more

The 49ers allowed 311 yards and 16 points during the Week 6 win over the Rams and play the Patriots on Sunday.

Analysis: It was a solid defensive performance from San Francisco, yet it provided little fantasy production with one takeaway and zero sacks. The Patriots continue to lean on their run game (167.2 YPG and 5.1 YPC), and QB Cam Newton being farther removed from his absence due to COVID-19 should help after the offense was sluggish last week. The 49ers D/ST ranks in the bottom half of the league with six takeaways and 10 sacks, making it a middling fantasy matchup for Week 7. However, starters Jaquiski…read more

The 49ers surrendered 43 points and 436 yards during the Week 5 loss to the Dolphins and play the Rams on Sunday.

Analysis: It was an absolute thrashing from Miami as QB Ryan Fitzpatrick averaged 12.5 yards per attempt, and it could have been even worse as it settled for five field goals. San Francisco's injury issues remain a significant problem going forward, and the matchup against a more-talented Rams offense limits the outlook for the 49ers D/ST in Week 6.

The 49ers allowed 18 offensive points and 267 yards during the 25-20 loss to the Eagles and play the Dolphins on Sunday.

Analysis: San Francisco had one takeaway, three sacks and gave up only 4.5 yards per play, but three giveaways from QB Nick Mullins set up Philly nicely. QB Ryan Fitzpatrick and the Dolphins are averaging 23.3 points and 347 yards and have protected the passer well (six sacks allowed) through four games, and they rank middle of the pack with five giveaways. However, Fitzpatrick's propensity for turnovers is well known, and he threw a pair of interceptions last week. The 49ers D/ST is still pretty banged…read more

The 49ers held the Giants to 231 yards and nine points during the Week 3 victory and play the Eagles on Sunday.

Analysis: San Francisco had zero issues against New York despite the massive injury concerns, totaling two sacks and three takeaways. QB Carson Wentz is off to an atrocious start in 2020 with two interceptions in each game plus three total fumbles (one loss), and he's also been sacked 11 times. Wentz and the Philly offense very well could turn things around this season, but as of now it makes for an attractive fantasy matchup for the 49ers D/ST, even with the injuries.

DLs Nick Bosa and Solomon Thomas suffered torn ACLs in Week 2 and are out for the season heading into Sunday's game against the Giants.

Analysis: It was a costly win against the Jets in the second game of the season, as DE Dee Ford (back) is also expected to miss at least one game. The matchup with the Giants in Week 3 remains an attractive option, but the 49ers are missing most of the teeth from a dominant front four while also missing their top corner Richard Sherman (calf). San Francisco has enough talent to remain on the fantasy radar in New York this week -- especially with RB Saquon Barkley (knee) sidelined -- but it's propensity…read more

CB Richard Sherman has an apparent leg injury and may be placed on injured reserve ahead of the Week 1 matchup with the Jets

Analysis: It would be a significant loss for the 49ers, who surrendered 24 points and 404 yards in the Week 1 loss to the Cardinals while recording one takeaway and two sacks. QB Kyler Murray had 230 passing yards and 91 rushing yards with two total touchdowns, but they won't be facing a dual-threat option of that caliber most weeks. A matchup with the Jets is a welcome sight, as New York managed only 17 points with two giveaways and three sacks allowed in the season opener. It's worth keeping an eye on…read more

The 49ers will play the Cardinals in the season opener Sunday afternoon.

Analysis: It's a solid matchup on paper for San Fran and its potent pass rush, as Arizona ranked tied-26th in sacks allowed (50) last season, and much of the offensive line is familiar faces. However, the addition of DeAndre Hopkins to the receiving corps completely changes the complexion of the offense, providing QB Kyler Murray a top-tier weapon for his second season. The 49ers D/ST is a high-floor option based on their success last season, but the Cardinals took good care of the ball (tied-ninth with…read more

The 49ers ranked second in total defense (281.8 YPG), eighth in scoring (19.4 PPG), tied-fifth in sacks (48) and sixth in takeaways (27) last season.

Analysis: The departure of DeForest Buckner can't be overstated, but if there's one team that can manage the talent loss, it's the 49ers. First-round pick DT Javon Kinlaw should step into the starting role, and the rest of the defense remains intact. Nick Bosa, Dee Ford and Arik Armstead should again lead one of the most potent pass rushes in the league.

The 49ers allowed 395 yards and 31 points to the Rams in Week 16 and play the Seahawks on Sunday.

Analysis: San Francisco struggled to stop the Rams for most of the contest with zero sacks and one takeaway, but that one takeaway proved pivotal as Fred Warner returned an interception for a touchdown. The 49ers still rank second in total defense (277.4 YPG), eighth in scoring (19.3 PPG), tied-fifth in takeaways (27) and fifth in sacks (47), but they're allowing 35.3 points in the last three games. QB Russell Wilson remains one of the most efficient signal callers in the league, but the Seahawks are…read more

The 49ers allowed 290 yards during the Week 15, 29-22 loss to the Falcons and play the Rams on Saturday.

Analysis: The Falcons scored on touchdown on the final play as the 49ers attempted a last-ditch lateral, and they provided little value with only two sacks and one takeaway. The return of CB Richard Sherman (hamstring) should help this weekend,as San Fran attempts to replicate its previous performance against Los Angeles after it gave up only 157 yards. The 49ers D/ST should be a solid option once again in Week 16.

The 49ers allowed 465 yards during the Week 14, 48-46 win over the Saints and play the Falcons on Sunday.

Analysis: The San Fran defense had its first major dud of the season, as it had only one sack and zero takeaways. Week 15 presents a much more friendly matchup, as the Falcons rank tied-21st in giveaways (21) and tied-24th in sacks allowed (41). Atlanta still has some quality weapons -- assuming Devonta Freeman (knee) and Julio Jones (shoulder) are available to play -- but there's no reason to suggest the San Francisco D/ST won't return to its more typical 2019 form as a solid fantasy option.

The 49ers allowed 283 yards during the Week 13, 20-17 loss to the Ravens and play the Saints on Sunday.

Analysis: San Francisco put forth a fantastic defensive effort, giving up only 4.6 yards per play and stifling the passing game, but QB Lamar Jackson still did just enough on the ground (16 carries for 101 yards and one TD) to help secure the win for Baltimore. Howver, only one sack and one takeway meant limited fantasy output. Week 14 presents another tough challenge versus New Orleans, again on the road. The 49ers D/ST has been good enough to trust against essentially all comers in 2019, but it's still…read more

The 49ers held the Packers to 198 yards and eight points in Week 12 and will play the Ravens on Sunday.

Analysis: San Francisco had zero problem shutting down QB Aaron Rodgers, as he was sacked five times and averaged a paltry 3.2 yards per pass. Week 13 brings forward a bigger challenge in QB Lamar Jackson, who's led Baltimore to 40-plus points in three straight games. The 49ers D/ST has proven it's worth standing by week in and week out regardless of matchup, but the Ravens are currently the hottest offense in the league and feature the MVP frontrunner. It's a solid idea to at least check out available…read more

The 49ers gave up 266 yards and 26 points to the Cardinals in Week 11 and will play the Packers on Sunday Night Football.

Analysis: San Fran had trouble stopping QB Kyler Murray on the ground (eight carries for 67 yards and one TD), but otherwise was able to hold Arizona's offense in check. The 49ers continue to be one of the top defenses in the league but the Packers represent a tough matchup. The San Francisco D/ST is a safe bet to get at least a couple sacks, but QB Aaron Rodgers' and Green Bay's ball security (only seven giveaways) keeps it a middling matchup, at best.

The 49ers gave up 336 yards in Monday's 27-24 overtime loss to the Seahawks and will play the Cardinals in Week 11.

Analysis: San Fran racked up five sacks and four takeaways, including a fumble return for a touchdown. The 49ers still rank second in the league in total defense (251.6 YPG), scoring (14.3 PPG) and sacks (35), while also being third in takeaways (20). Rookie QB Kyler Murray and the Cardinals are tied for the league lead in giveaways (six), but the 49ers remain a quality fantasy option in Week 11.