| Date | Week | Type | Player(s) | From | To | By |
|---|---|---|---|---|---|---|
| Dec 12, 12:19pm | 15 | Lineup | Brian Burns LB - NYG | LB | BN | Barb |
| Dec 12, 12:19pm | 15 | Lineup | Christian Rozeboom LB - LAR | BN | LB | Barb |
| Dec 12, 12:19pm | 15 | Lineup | Zach Allen DL - DEN | BN | DL | Barb |
| Dec 12, 12:19pm | 15 | Lineup | Cade Otton TE - TB | W/T | BN | Barb |
| Dec 12, 12:19pm | 15 | Lineup | Khalil Shakir WR - BUF | BN | W/T | Barb |
| Dec 12, 10:08am | 15 | Lineup | Deommodore Lenoir DB - SF Q | DP | BN | |
| Dec 12, 10:08am | 15 | Lineup | E.J. Speed LB - IND | BN | DP | |
| Dec 12, 10:07am | 15 | Lineup | Braelon Allen RB - NYJ | R/W/T | W/R | |
| Dec 12, 10:07am | 15 | Lineup | Bucky Irving RB - TB | W/R | R/W/T | |
| Dec 12, 7:20am | 15 | Drop | SF's BowMen | Waivers | El Butre | |
| Dec 12, 7:20am | 15 | Add | Los Angeles Rams DEF | Free Agents | SF's BowMen | El Butre |
| Dec 12, 7:17am | 15 | Lineup | Jordan Addison WR - MIN | W/R | W/T | El Butre |
| Dec 12, 7:17am | 15 | Lineup | Deebo Samuel Sr. WR - SF | W/R | BN | El Butre |
| Dec 12, 7:17am | 15 | Lineup | George Kittle TE - SF | R/W/T | W/T | El Butre |
| Dec 12, 7:17am | 15 | Lineup | Brock Bowers TE - LV | W/T | R/W/T | El Butre |
| Dec 12, 7:17am | 15 | Lineup | Cooper Kupp WR - LAR | W/T | W/R | El Butre |
| Dec 12, 7:17am | 15 | Lineup | Gus Edwards RB - LAC | BN | W/R | El Butre |
| Dec 12, 7:14am | 15 | Lineup | Tre'von Moehrig DB - LV | DP | DB | El Butre |
| Dec 12, 7:14am | 15 | Lineup | DeShon Elliott DB - PIT | DB | DP | El Butre |
| Dec 12, 7:12am | 15 | Drop | Ray Davis RB - BUF | SF's BowMen | Waivers | El Butre |
| Dec 12, 7:12am | 15 | Add | Patrick Taylor RB - SF | Free Agents | SF's BowMen | El Butre |
| Dec 12, 7:08am | 15 | Lineup | DEF | BN | El Butre |