The 49ers recorded two sacks and two takeaways, including a pick-six, in the 48-27 win over the Colts in Week 16.

Analysis: The 49ers allowed QB Philip Rivers to throw for 277 yards, two touchdowns and an interception, but their defense held strong in the second half to secure the win. This defense has some serious flaws, as it ranks 23rd in pass defense while forcing just 16 turnovers (20th) and recording a league-worst 1.2 sacks per game, but it does a good job in the red zone and has allowed a mere 21.3 points per game (11th). Nevertheless, facing the Bears in Week 17 will be difficult. The Bears have produced…read more

The 49ers recorded no sacks or takeaways in the 37-24 win over the Titans in Week 15.

Analysis: This was a disappointing outing for the 49ers, whose pass rush has evaporated without DE Nick Bosa (knee), ranking last in the league with 1.1 sacks per game. This unit has still been steady with 20.9 points allowed per game (11th), but it has only contributed 14 takeaways (21st). Perhaps most importantly for its Week 16 clash against the Colts, the 49ers have given up a league-low 3.7 yards per carry this season. The Colts' main offensive threat is RB Jonathan Taylor because 44-year-old QB…read more

The 49ers recorded three sacks and two takeaways in the 26-8 win over the Browns in Week 12.

Analysis: This was an outstanding performance, but it has been an underwhelming season overall, as the 49ers have produced a league-worst 1.2 sacks per game while adding just 14 takeaways (20th). However, it has provided a decent floor at least with 20.7 points allowed per game (eighth). Now, the 49ers face the Titans in Week 15. The Titans just put up 31 points against a decent Browns defense last week, but they still rank 31st with 15.5 points allowed per game. Furthermore, QB Cam Ward has been sacked…read more

The 49ers recorded two takeaways and a sack in the 20-9 win over the Panthers in Week 12.

Analysis: This wasn't a dominant effort but it was good enough for fantasy purposes, and now the 49ers garner an excellent Week 13 matchup versus the Browns, who will start QB Shedeur Sanders for the second straight game. In his first start, Sanders completed 55.0 percent of his passes for 209 yards (10.5 YPA), a touchdown -- a screen pass that RB Dylan Sampson took 66 yards -- and an interception. Sanders doesn't push the ball down field but avoided mistakes against the Raiders, but the 49ers will…read more

The 49ers recorded three takeaways in the 41-22 win over the Cardinals in Week 11.

Analysis: The 49ers looked invigorated, as they entered this game with just seven turnovers but now rank 23rd with 10 total on the season. Overall, this is a middling defense, however, as it has given up 22.9 points per game (15th) while producing a league-worst 1.1 sacks per game. Their pass defense ranks 28th in the league, which is cause for some amount of concern against the Panthers, as QB Bryce Young just threw for 448 yards against the Falcons. But overall, the Panthers have scored just 20.7…read more

The 49ers recorded a sack and no takeaways in the 42-26 loss to the Rams in Week 10.

Analysis: The defensive struggles continue, as the 49ers have recorded just seven takeaways (28th) and a league-low 1.2 sacks per game. They have given up 23.0 points per game (15th) while having the 22nd-ranked pass defense. However, they draw an intriguing Week 11 matchup versus the Cardinals, who will have QB Jacoby Brissett under center but won't have top WR Marvin Harrison (appendix) in the fold. Still, the Cardinals have scored at least 22 points in each of Brissett's starts, and while Brissett has…read more

The 49ers recorded two sacks in the 34-24 win over the Giants in Week 9.

Analysis: The 49ers have the worst pass rush in the league without DE Nick Bosa, producing a league-worst 1.2 sacks per game. This has led to 6.4 net passing yards allowed per attempt (21st), but the team has been sturdy in the red zone, giving up just 20.9 points per game (10th). Now, they face the high-flying Rams, who will have both WRs Puka Nacua and Davante Adams in the fold. The Rams have scored 26.1 points per game (eighth) while turning the ball over just seven times (eighth). There's simply too…read more

The 49ers recorded a takeaway and no sacks in the 26-15 loss to the Texans in Week 8.

Analysis: The 49ers' pass defense continues to struggle, as it was picked apart by an injury-riddled Texans team, and it now rounds out as the 22nd-ranked pass defense. Still, it has held its own with 20.5 points allowed per game (eighth), but its upside has been pitiful with a league-worst 1.1 sacks per game and just seven takeaways (22nd). Now, they face the Giants, who have performed well of late but will be without RB Cam Skattebo (ankle). Overall, there's an intriguing opportunity because QB Jaxson…read more

The 49ers recorded two sacks and a takeaway in the 20-10 win over the Falcons in Week 7.

Analysis: The 49ers have given up 19.3 points per game (seventh) while forcing six turnovers (23rd) and averaging just 1.3 sacks per game (31st). Their upside has been highly disappointing, but they have been overall steady with the 18th-ranked pass defense. Now, they face the Texans, who have struggled this season with the 23rd-ranked pass offense and 21st-ranked scoring offense. They rarely turn the ball over, but QB C.J. Stroud has been sacked 2.5 times per game. That opens the door for some fantasy…read more

The 49ers recorded a sack and no takeaways in the 30-19 loss to the Buccaneers in Week 6.

Analysis: The 49ers predictably struggled against one of the league's top offenses, but their struggles extend throughout the season. They have registered seven sacks (31st) and five takeaways (21st) while giving up 21.3 points per game (15th). They draw a home Week 7 matchup versus the Falcons, who have scored just 20.0 points per game (27th) despite featuring the No. 1 run offense in the league. Thus, 49ers D/ST should have a decent floor this week, even if the ceiling is lowered due to the Falcons'…read more

The 49ers recorded a sack and two takeaways in the 26-23 overtime win over the Rams in Week 5.

Analysis: The 49ers are ranked sixth in the league with 19.6 points allowed per game, but the sturdy floor hasn't provided much upside, as they also have just six sacks (29th) and five takeaways (17th). They run into a tough Week 6 matchup on the road versus the Buccaneers, who likely won't have WR Mike Evans (hamstring), although they've been just fine without him, as they have averaged 334.0 passing yards per game without him. Furthermore, they have turned the ball over just twice this year. 49ers D/ST…read more

The 49ers recorded no sacks or takeaways in the 26-21 loss to the Jaguars in Week 4.

Analysis: The 49ers lost DE Nick Bosa (torn ACL) in the previous game, and his impact was clearly missing in the team's first loss of the season. Their pass rush only picked up five sacks through the first three games anyway, but Bosa accounted for 2.0 of those. Now, they face the Rams on a short week. The Rams have impressed with 25.0 points per game while turning the ball over just four times, and they have the third-ranked pass offense in the league. The 49ers still have a sturdy secondary, but it…read more

The 49ers recorded a sack and a takeaway in the 16-15 win over the Cardinals in Week 3.

Analysis: The 49ers will be without DE Nick Bosa (torn ACL) for the rest of the season. Bosa accounted for 2.0 of the team's 5.0 sacks this season. The defense should take a fairly significant step back without him, at least in real-life terms, but there's room for error considering it is the third-ranked scoring defense and fifth-ranked passing defense heading into the Week 4. The Jaguars have significant weapons but haven't really put it together this season. However, they haven't provided much fantasy…read more

The 49ers recorded three sacks and a takeaway in the 26-21 win over the Saints in Week 2.

Analysis: The 49ers took advantage of a favorable matchup versus the Saints, and now they get another intriguing opponent with the Cardinals coming to town in Week 3. The Cardinals have put up 47 points through two weeks against the Saints and Panthers while giving up just one turnover. The 49ers will be the best defense they have faced. Cardinals QB Kyler Murray is healthy and has protected the ball well so far, but he hasn't generated many explosive plays with his arm. The 49ers are equipped to contain…read more

The 49ers recorded a sack and two fumble recoveries in the 17-13 win over the Seahawks in Week 1.

Analysis: The 49ers shut down the Seahawks through the air and on the ground, and they get a highly favorable matchup in Week 2 against the Saints. During the opener, Saints QB Spencer Rattler was sacked just once while the team didn't turn the ball over. However, Rattler finished with just 4.7 yards per attempt while the offense looked lackluster. Even with the steps back that the 49ers have taken defensively, they're in a must-start matchup this week.

The 49esr placed S Malik Mustapha (knee) on the PUP list Tuesday.

Analysis: The 49ers were expecting this and acted accordingly, signing Jason Pinnock (heel) this offseason to start at free safety. Still, this defense was gutted during the offseason, losing starters LB Dre Greenlaw, CB Charvarius Ward, DT Javon Hargrave and S Talanoa Hufanga. It finished the 2024 season with the fourth-worst scoring defense, too. That doesn't bode well for the long-term outlook, but facing the Seahawks -- who had a brutal offensive line last year -- could still be favorable despite…read more

The 49ers lost four starters this offseason but drafted DE Mykel Williams with the No. 11 pick.

Analysis: LB Dre Greenlaw, CB Charvarius Ward, DT Javon Hargrave and S Talanoa Hufanga all departed, so the 49ers will need positive outcomes from their unproven players to hold their own. They added CB Eli Apple to add depth in the secondary behind CB Renardo Green -- 2024 second-round pick -- and veteran CB Demmodore Lenoir (hip). Green showed upside last season and could become a lockdown corner. However, the defensive line will be the biggest needle-mover, as Hargrave is a massive loss and Williams…read more

The 49ers recorded two sacks in the 40-34 loss to the Lions in Week 17.

Analysis: The 49ers have allowed 24.3 points per game (22nd), and they have the fourth-ranked pass defense. Now, they head to Arizona for a Week 18 matchup that won't impact the playoff picture. The Cardinals have scored 22.1 points per game (15th) while giving up 20 turnovers (17th). The Cardinals have scored 30 points in back-to-back games and have an explosive upside, so 49ers D/ST should carry more risk than meets the eye in fantasy championships.

The 49ers recorded no sacks or takeaways in the 29-17 loss to the Dolphins in Week 16.

Analysis: The 49ers have given up 23.2 points per game this season (17th) while forcing just 17 turnovers (14th). That doesn't scream upside, and the Week 17 matchup versus the Lions is far too tough to take on. The Lions lead the league with 32.8 points per game while giving up just 13 turnovers (seventh). Don't take on this level of risk in fantasy championships.

The 49ers recorded no sacks or takeaways in the 12-6 loss to the Rams in Week 15.

Analysis: This game was played in inclement weather, and neither side could generate any meaningful offense. Now, the 49ers will face a tougher task in Week 16, going on the road to face the Dolphins. While the Dolphins rank 15th in the league in passing offense and 24th in scoring offense, the Dolphins have decent upside with so much speed at their disposal. The 49ers could certainly keep up, but they're a risky bet in most redraft formats this week.

The 49ers recorded seven sacks and a fumble recovery in the 38-13 win over the Bears in Week 14.

Analysis: The 49ers took advantage of a highly favorable matchup against the Bears, but their competition will be far tougher in Week 15 versus the Rams, who have scored 20-plus points in seven of the last eight games while forking up just five turnovers in that stretch. Since the Rams are a familiar divisional foe, there should be a decent floor, but 49ers D/ST still feels like a high-risk option, especially as it enters the week ranked 21st with 23.7 points allowed per game.

The 49ers didn't record a sack or a takeaway in the 35-10 loss to the Bills in Week 13.

Analysis: The 49ers couldn't capitalize on snowy conditions without DE Nick Bosa (oblique), and it's unclear if Bosa will be back in Week 14 versus the Bears. If he's back, it raises the 49ers' upside significantly, as QB Caleb Williams has been sacked a league-high 49 times through 12 games. There should be a decent floor regardless, as the Bears have posted 20.1 points per game (23rd), making 49ers D/ST a top-10 option.

The 49ers recorded two sacks and no takeaways in the 38-10 win over the Packers in Week 12.

Analysis: The 49ers could be without starting slot cornerback Deommodore Lenoir (knee) in Week 13 versus the Bills, which could be a major issue, as the Bills have the third-ranked scoring offense while coughing up just seven turnovers (second). Even if Lenoir plays, the 49ers D/ST will have too much risk this week as a defense that has allowed 23.6 points per game (20th).

The 49ers recorded four sacks and an interception in the 20-17 loss to the Seahawks in Week 11.

Analysis: The 49ers rank 12th in the league with 2.6 sacks per game and eighth with 16 takeaways, and now they'll travel to Green Bay for a Week 12 matchup versus the Packers. CB Charvarius Ward (personal) will be back in the fold for the 49ers, which will be a massive boost against a Packers offense that ranks third in the league with 7.7 YPA and eighth with 25.0 points per game. QB Jordan Love has also tossed a career-high 11 interceptions, providing plenty of upside for 49ers D/ST, but fantasy…read more

The 49ers recorded two sacks in the 23-20 win over the Buccaneers in Week 10.

Analysis: The 49ers' defense has been mediocre this season, as it ranks 17th in points allowed per game and 18th with 22 sacks. Now, they may be without top CB Charvarius Ward (personal) in Week 11 versus the Seahawks, who also have top WR DK Metcalf (knee) uncertain. Metcalf would be a bigger loss than Ward would be for the 49ers, but regardless, there's some additional risk for the 49ers this week. Try swapping out 49ers D/ST in 12-team formats if Metcalf comes back in, but it's not a bad option either…read more

The 49ers recorded two interceptions and two sacks in the 30-24 win over the Cowboys in Week 9.

Analysis: The 49ers could be without top CB Charvarius Ward (personal) in Week 10 versus the Buccaneers, who will be without top WRs Mike Evans (hamstring) and Chris Godwin (ankle) while WR Jalen McMillan (hamstring) looks like he'll be questionable, at best. That leaves little upside for the Buccaneers, so even though the 49ers have allowed 22.8 points per game (16th), there's enough upside for this defense with 15 turnovers (fourth). This unit should be a fine start in 12-team formats.

The 49ers recorded two sacks and two interceptions in the 28-18 loss to the Chiefs in Week 7.

Analysis: The 49ers held QB Patrick Mahomes to just 154 passing yards, and this team has been solid overall this year with 13 takeaways (fourth) while allowing 22.7 points per game (16th). They're positioned well in Week 8 versus the Cowboys, too. The Cowboys have averaged just 21.0 points per game (20th) while coughing up 11 turnovers (20th). Most of all, the lack of depth behind Cowboys WR CeeDee Lamb should provide a solid floor for 49ers D/ST.

The 49ers recorded two interceptions and a sack in the 36-24 win over the Seahawks in Week 6.

Analysis: This defense has taken a slight step back this season, but it's still a solid unit with 21.7 points allowed per game (12th) and 11 takeaways (sixth). It's always difficult to start a defense against the Chiefs, but the Chiefs have scored 23.6 points per game (15th) while giving up eight turnovers (25th) through five games. Thus, 49ers D/ST has some upside this week, especially with the injury issues for the Chiefs' wide receivers -- namely Rashee Rice (knee). It's understandable to bench this…read more

The 49ers recorded a sack and an interception in the 24-23 loss to the Cardinals in Week 5.

Analysis: The 49ers have been solid across the board, recording eight takeaways (seventh) and 15 sacks (eighth) while allowing 21.2 points per game (12th). This matchup versus the Seahawks presents significant risk, as QB Geno Smith leads the league with 1,466 passing yards, but Smith has also been sacked a whopping 18 times while the Seahawks have turned the ball over seven times (21st). This is an excellent matchup for DFS tournaments, and there's enough upside for deep-league formats.

The 49ers recorded six sacks and three takeaways in the 30-13 win over the Patriots in Week 4.

Analysis: The 49ers are now tied for fourth in the league with 14 sacks and fifth with seven takeaways. They have allowed just 20.5 points per game (10th). This defense should be talented enough to pay off in Week 5 versus the Cardinals, who have posted 24.0 points per game (13th) despite scoring just 27 combined points over the past two weeks. The 49ers' ability to stop the run should provide the 49ers D/ST with a high floor this week even if the ceiling is lowered.

The 49ers recorded three sacks and an interception in the 27-24 loss to the Rams in Week 3.

Analysis: The 49ers' defense hasn't been explosive this season, recording eight sacks (14th) and four takeaways (eighth) through three games while giving up 23-plus points in two of those outings. The Week 4 matchup against the Patriots feels like a get-right game. The Patriots have scored just 13 points per game (31st), and while they have turned the ball over just once, their quarterbacks have been sacked 11 times. The 49ers D/ST should be considered a must-start option this week because of its high…read more

The 49ers recorded three sacks and two takeaways in the 23-17 loss to the Vikings in Week 2.

Analysis: The 49ers' offense couldn't pick up the slack, leading to the 49ers' first loss, but the defense managed to force two turnovers for the second straight game. This unit also has just five sacks. The Week 3 matchup against the Rams is as good as it gets, as WRs Cooper Kupp (ankle) and Puka Nacua (knee) will be out, leaving an assortment of mediocre receivers to handle the workload. There's a high floor for 49ers D/ST this week, and the ceiling is even higher after QB Matthew Stafford was sacked…read more

The 49ers recorded a sack and two takeaways in the 32-19 win over the Jets in Week 1.

Analysis: Jets QB Aaron Rodgers got the ball out of his hands quickly, lessening the impact of the 49ers' pass rush, which has a good chance to return to its former glory in Week 2 versus the Vikings. While Vikings QB Sam Darnold was sacked just once in the opener, he has a history of high sack rates and a career 65:57 TD:INT ratio. The door is wide open for 49ers D/ST to be a top-5 defensive unit in Week 2, especially with Vikings WR Jordan Addison (ankle) heading in the wrong direction.

The 49ers won't have LB Dre Greenlaw (Achilles) to start the season Week 1 versus the Jets.

Analysis: The Niners picked up LB De'Vondre Campbell to fill the void, and he may retain the role even when Greenlaw returns. Regardless, this defense is returning most of its team from last year when they ranked third in scoring defense and fifth in takeaways, but they'll have new DC Nick Sorensen calling the plays. The matchup against the Jets is tough to track, as it will hinge on how good QB Aaron Rodgers looks in his first game since his Achilles injury, but it will help that the Jets' offensive…read more

The 49ers signed DE Leonard Floyd in March.

Analysis: Floyd has posted at least 9.0 sacks in each of the last four seasons, and he's expected to start opposite Nick Bosa on the defensive line. Their front seven has always been a strong suit, but there are some questions about the secondary with S Talanoa Hufanga (knee) still rehabbing from a torn ACL. Hufanga shouldn't be out long, though, and the most of their secondary is returning from last year, when it allowed just 17.5 points per game (third). Thus, 49ers D/ST should be among the first…read more

The 49ers recorded two interceptions and no sacks in the 24-21 win over the Packers in the divisional round.

Analysis: The pass rush struggled to get home against QB Jordan Love, but it did force him into two costly interceptions. The Lions' offensive line is one of the best in the league and may be able to keep QB Jared Goff upright. The 49ers likely still have the edge, though, as they ranked fifth in the league with 28 regular-season turnovers and third with 17.5 points allowed per game. If the 49ers can get out to an early lead, it will put a lot of pressure on Goff to drive the ball downfield. He has…read more

The 49ers defense is expected to be fully healthy for the divisional-round game against the Packers.

Analysis: The 49ers rested some starters in Week 18, providing an effective two-week bye ahead of this matchup versus the Packers. This defense was dominant during 2023, ranking third with 17.5 points allowed per game and fifth with 28 takeaways. Nevertheless, the Packers pose a serious threat after posting 48 points against the Cowboys in the wild-card round while posting just six turnovers over the last nine games. It wouldn't be surprising if the Packers could reach 20 points in this matchup, but the…read more

The 49ers recorded two interceptions and a sack in the 27-10 win over the Commanders in Week 17.

Analysis: This defense has allowed just 16.9 points per game (third) while registering a whopping 46 sacks (sixth) and 27 turnovers (third). Still, it will be difficult to trust 49ers D/ST in Week 18 because they likely won't play their starters all game, if at all. The Rams are a worthy matchup even if the 49ers dress everyone, as they rank eighth with 23.9 points per game and fifth with just 17 turnovers. Thus, 49ers D/ST probably belongs on the bench outside of deeper formats in Week 18.

The 49ers recorded two sacks and no takeaways in the 33-19 loss to the Ravens in Week 16.

Analysis: The 49ers offense coughed up four turnovers, which didn't do its defense any favors. Still, this team allowed 252 passing yards and two passing touchdowns and struggled to contain QB Lamar Jackson as a runner. Still, this defense is fantastic. It ranks third with 17.8 points allowed per game and second with 25 takeaways, and it receives a pristine matchup in Week 17 against the Commanders, who will start QB Jacoby Brissett. Brissett is a fine starter, but his offense won't instantly improve…read more

The 49ers recorded three sacks and two interceptions in the 45-29 win over the Cardinals in Week 15.

Analysis: This remains a top-3 defense in the league. It has given up just 16.7 points per game (second) while forcing a league-high 25 turnovers and recording 43 sacks (seventh). Nevertheless, they run into a worthy opponent in Week 16 when the Ravens come to town. The Ravens rank fourth in the league with 27.4 points per game, and now they have WR Odell Beckham making a real impact in the offense. The 49ers may be good enough to slow this offense down still, but fantasy managers in playoffs may want a…read more

The 49ers recorded four sacks and two interceptions in the 28-16 win over the Seahawks in Week 14.

Analysis: The 49ers faced backup QB Drew Lock and contained him with the help of a couple timely takeaways. Through 13 games, the 49ers have allowed a league-low 15.8 points per game while forcing 23 turnovers (third). The team is in a strong position in Week 15 against the Cardinals, who have averaged a modest 19.8 points per game with QB Kyler Murray under center. Murray has avoided sacks well and has thrown just two picks in four games, so maybe there's a lower ceiling this week. But this defense is…read more

The 49ers recorded three sacks and no takeaways in the 42-19 win over the Eagles in Week 13.

Analysis: This was a dominant effort, as the 49ers bent but didn't break against one of the best offenses in the league. Now, they'll face the Seahawks for the second time in three weeks. On Thanksgiving Day, this defense allowed just six points to the Seahawks while recording two takeaways and six sacks. After an excellent performance against the Eagles, we should have confidence that the 49ers can repeat their Week 12 performance against the Seahawks, making them an excellent option in Week 14.

The 49ers recorded six sacks and two takeaways in the 31-13 win over the Seahawks in Week 12.

Analysis: The 49ers have allowed just 30 total points over the last three games while posting 15 sacks and eight turnovers. This is the best defense in the league, allowing a league-low 15.5 points per game and forcing 21 turnovers (second). Still, there's substantial risk for 49ers D/ST this week against the Eagles, who are tied with the 49ers for 3rd in the league with 28.2 points per game. The Eagles do turn the ball over too much, ranking 18th with 16 turnovers. Perhaps that provides some upside in…read more

The 49ers recorded four sacks and two takeaways in the 27-14 win over the Buccaneers in Week 11.

Analysis: The 49ers have given up a league-low 15.7 points per game this season while forcing a whopping 19 turnovers (second). They're an excellent starting option in nearly every matchup, and that won't change in Week 11 versus the Seahawks. RB Kenneth Walker (oblique) will likely be out. Seahawks QB Geno Smith (elbow) appears on track to play but likely won't be fully healthy, and if he ends up sitting out, QB Drew Lock will get the nod. Either way, this is a great opportunity to 49ers D/ST to stack…read more

The 49ers recorded four sacks and two takeaways in the 27-14 win over the Buccaneers in Week 11.

Analysis: The 49ers have given up a league-low 15.7 points per game this season while forcing a whopping 19 turnovers (second). They're an excellent starting option in nearly every matchup, and that won't change in Week 11 versus the Seahawks. RB Kenneth Walker (oblique) will likely be out. Seahawks QB Geno Smith (elbow) appears on track to play but likely won't be fully healthy, and if he ends up sitting out, QB Drew Lock will get the nod. Either way, this is a great opportunity to 49ers D/ST to stack…read more

The 49ers recorded five sacks, two interceptions and two fumble recoveries in the 34-3 win over the Jaguars in Week 10.

Analysis: This was a classic performance by the 49ers against a loaded, albeit underperforming, offense. The 49ers have forced 17 turnovers (fifth) while giving up just 15.9 points per game (third). Their pass rush is clicking better now that it added DE Chase Young, as the team has produced eight sacks over the last two weeks. They're an autostart most weeks, and fantasy managers should be confident in this unit against the Buccaneers, who have averaged 19.8 points per game (22nd).

The 49ers recorded three sacks and a fumble recovery in the 31-17 loss to the Bengals in Week 8.

Analysis: This defense was put into some difficult positions because of the 49ers' mistake-prone offense, but we should still consider this unit was of the premier options for fantasy purposes in most matchups. The Niners have allowed 17.5 points per game (fourth) while forcing 13 turnovers (seventh). They'll be vulnerable this week, though, as the Jaguars have produced 24.1 points per game (10th), including at least 20 points in five straight games. There's plenty of upside because the Jags have also…read more

The 49ers recorded an interception and no sacks in the 22-17 loss to the Vikings in Week 7.

Analysis: This was a highly disappointing outcome overall, but it wasn't particularly bad considering the 49ers had to defend after their offense turned the ball over three times. However, it's still notable, especially with a risky matchup in Week 8 versus the Bengals. The Bengals have struggled this season with just 16.7 points per game (28th), but now QB Joe Burrow is coming off a bye and may look even healthier than before. This offense has massive firepower that can break any game open, so fantasy…read more

The 49ers recorded two sacks and two interceptions in the 19-17 loss to the Browns in Week 6.

Analysis: This loss wasn't on the defense, although it was a bit underwhelming for fantasy purposes against a backup quarterback. This unit is still a weekly starter, as it has allowed a league-low 14.5 points per game while forcing seven turnovers (11th). We should feel especially confident against the Vikings, who scored just 13 points on offense versus the Bears without Justin Jefferson (hamstring) last week.

The 49ers recorded four sacks and three interceptions in the 42-10 win over the Cowboys in Week 5.

Analysis: This was a dominant performance against a good offense. The 49ers have allowed a league-low 13.6 points per game while forcing nine turnovers (sixth) and recording 13 sacks (17th). This unit is a must-start on a weekly basis, and Week 6 versus the Browns is no different. QB Deshaun Watson (shoulder) isn't guaranteed to play, and there's no dangerous backup in Cleveland. Even if Watson can go, this offense isn't too threatening. Through three games, Watson posted a 4:2 TD:INT ratio while getting…read more

The 49ers recorded a sack and no takeaways in the 35-16 win over the Cardinals in Week 4.

Analysis: This was an underwhelming performance, but it wasn't damaging for fantasy purposes. The 49ers now rank third with 14.5 points allowed per game, 12th with five takeaways and 22nd with just nine sacks, making it a safe weekly play even if it hasn't hit its ceiling. They will be a risky play in Week 5 versus the Cowboys, who rank fourth with 31 points per game this year while giving up just one turnover. There's certainly some upside considering QB Dak Prescott turned the ball over 16 times last…read more

The 49ers recorded two sacks and an interception in the 30-12 win over the Giants in Week 3.

Analysis: This was far from a ceiling outcome against the Giants, but the 49ers still rank seventh in the league with five takeaways. Their Week 4 opponent -- the Cardinals -- have been outperforming expectations this season, including putting up 28 points against the Cowboys last week. It's hard to tell when they'll come back to earth, but it's worth noting that QB Joshua Dobbs has been sacked just five times and hasn't thrown a pick through three games. The 49ers have one of the best front sevens in…read more

The 49ers recorded two interceptions and a sack in the 30-23 win over the Rams in Week 2.

Analysis: After producing five sacks in the opener, the 49ers took a step back against their division rival. They'll look to get back on track with a juicy Week 3 matchup versus the Giants, as QB Daniel Jones has been sacked 10 times while posting a 2:3 TD:INT ratio through two games. Now, the Giants will likely be without RB Saquon Barkley, putting more pressure on Jones and likely causing more mistakes. 49ers D/ST is a top-5 unit this week.

The 49ers recorded five sacks and two interceptions in the 30-7 win over the Steelers in Week 1.

Analysis: This is one of the toughest defensive fronts in the league, and it will keep 49ers D/ST elite all year. They have an excellent opportunity in Week 2 versus the Rams. While the Rams scored 30 points in Week 1 versus the Seahawks, they still are lacking elite weapons on offense. The 49ers can take advantage of those flaws, and the Rams' mediocre offensive line should struggle against the likes of DE Nick Bosa and DT Javon Hargrave. Consider this unit a top option in Week 2.

It's unclear whether Nick Bosa will play unless he receives a contract extension.

Analysis: The 49ers have an elite defensive line when Bosa is in the lineup, and it's still a top-10 unit when Bosa is out. Still, their upside is limited when the reigning Defensive Player of the Year is out, as he posted 18.5 sacks in 2022. There should be decent upside and a rock-solid floor in Week 1 versus the Steelers regardless, as QB Kenny Pickett posted a 7:9 TD:INT ratio as a rookie.

DE Nick Bosa did not report to training camp and is holding out for a new contract.

Analysis: Bosa is using his leverage after posting 34 sacks over his last 33 games and being named the 2022 NFL Defensive Player of the Year. He'll almost certainly be signed by Week 1. The 2019 first-round pick was the only 49ers player to post more than five sacks last season, as he put up 18.5 sacks. He'll be joined by DT Javon Hargrave, who signed with the team after posting 11 sacks last year. This takes a lot of pressure off Bosa and forms one of the top defensive lines in the league, providing a…read more

The 49ers signed DT Javon Hargrave in March.

Analysis: The 49ers already had one of the best defensive lines in the league, and now they're adding a player who piled up 11 sacks last season. Keeping their pass rush elite is key to this defense's success, as they forced their opponents into a league-high 20 interceptions in 2022. We should expect to see a similar level of excellence from this unit in 2023 now that Hargrave is in the fold and 2022 second-round pick DE Drake Jackson has a full offseason under his belt. 49ers D/ST should be one of the…read more

The 49ers recorded two interceptions and a sack in the 19-12 win over the Cowboys in the divisional round.

Analysis: Two of the best defenses in the league will face off against each other in the NFC Championship. During the regular season, the 49ers recorded a league-low 16.3 points allowed per game, and they finished second with 30 turnovers and 10th with 44 sacks. For DFS purposes, the 49ers D/ST stacks up as a solid option compared to the other options this week, especially because QB Jalen Hurts was sacked 38 times through 15 games. But there's still a ton of risk against the third-ranked offense (28.1…read more

The 49ers recorded three sacks and two takeaways in the 41-23 win over the Seahawks in the wild-card round.

Analysis: The Seahawks stuck around in the first half, but the 49ers completely shut them down in the second. This unit continues to be excellent, as it has produced at least two turnovers in eight of the last nine games, including two four-turnover performances. Cowboys QB Dak Prescott showcased his elite upside last week, but he did throw 15 interceptions in addition to four fumbles over 12 regular-season games. That leads us to believe 49ers D/ST has excellent upside this week, but Prescott's arm and…read more

The 49ers recorded four takeaways and three sacks in the 38-13 win over the Cardinals in Week 18.

Analysis: The 49ers were an elite defense during the regular season, as they finished with a league-low 16.3 points allowed per game while putting up 30 takeaways (second). They're excellent against the run, too, and that will be key against the Seahawks, who need to pound the football to win this game. Since the Week 11 bye, the Seahawks have averaged a modest 21.4 points per game while giving up 10 turnovers over seven games. 49ers D/ST has high upside on a weekly basis, and there should at least be a…read more

The 49ers recorded two interceptions and no sacks in the 37-34 win over the Raiders in Week 17.

Analysis: Perhaps the 49ers looked past QB Jared Stidham, but they should be ready to bounce back in Week 18 with major seeding on the line. The 49ers have an elite defense with a league-low 16.5 points allowed per game in addition to 26 turnovers (fourth) and 41 sacks (11th). QB David Blough will start for the Cardinals. He made his first start since 2019 in Week 17, and he was inefficient with 5.5 YPA. RB James Conner (shin) and WR DeAndre Hopkins (knee) are out, so Blough is slated to struggle. 49ers…read more

The 49ers recorded two sacks and two takeaways in the 37-20 win over the Commanders in Week 16.

Analysis: The 49ers haven't given up more than 20 points in a game since Week 7, as they have allowed a league-low 15.3 points per game while forcing 24 turnovers (fourth). They are also tied for seventh in the league with 41 sacks. Now, they will face the Raiders, who have benched QB Derek Carr and will start QB Jared Stidham, who has never started a game and has just 61 pass attempts, amounting to 5.6 YPA and a 2:4 TD:INT ratio. The Raiders are in serious trouble with Stidham under center, so the 49ers…read more

The 49ers recorded three sacks and a fumble recovery in the 21-13 win over the Seahawks in Week 15.

Analysis: The 49ers have given up a league-low 15 points per game this season while forcing 22 turnovers (fourth) and recording 39 sacks (seventh). There are only a few teams where the 49ers D/ST should be benched against, and the Commanders certainly don't fit into that bucket. The Commanders rank 25th in the league with 18.9 points per game in addition to 17 turnovers (13th).

The 49ers recorded two interceptions and a fumble recovery in the 35-7 win over the Buccaneers in Week 14.

Analysis: The 49ers are tied for fifth in the league with 21 takeaways, and they have given up a league-low 15.2 points per game following the complete shutdown of QB Tom Brady in Week 14. They'll carry some extra risk in Week 15 against the Seahawks, who rank sixth with 26.3 points per game. Still, 49ers D/ST can't be benched in season-long leagues because of its upside, especially this week because the Seahawks have turned the ball over 19 times this year (26th).

The 49ers recorded three sacks and three takeaways, one of which they returned for a touchdown, in the 24-17 win over the Dolphins in Week 13.

Analysis: The Dolphins have an elite offense, and the 49ers shut them down anyway. The 49ers haven't given up more than 17 points in a game since Week 7 versus the Chiefs, and they have allowed a league-low 15.8 points per game. With 36 sacks (sixth) and 18 takeaways (eighth), they're coming through for fantasy managers as well. The 49ers D/ST should be a fine play the rest of the season, and it will have a high floor in Week 14 versus the Buccaneers, who rank 27th with 18.1 points per game.

The 49ers recorded two fumble recoveries and a sack in the 13-0 win over the Saints in Week 12.

Analysis: The 49ers have given up a league-low 15.7 points per game in addition to producing 33 sacks (eight). They have produced for fantasy purposes in nearly every game this season, so this unit will be tough to bench. But there is still substantial risk, as the Dolphins have scored at least 30 points in four straight games while coughing up just two turnovers. There may be decent pivots available on waivers this week.

The 49ers recorded three sacks in the 38-10 win over the Cardinals in Week 11.

Analysis: The 49ers weren't particularly tested with QB Colt McCoy under center for the Cardinals, but they still rank fourth with 17.3 points allowed per game and fourth with 32 sacks. Saints QB Andy Dalton has been well-protected, as he has been sacked just 13 times through eight games. However, the Saints have given up 19 turnovers (30th) this year, so 49ers D/ST has a massive opportunity in Week 12.

The 49ers recorded three sacks and an interception in the 22-16 win over the Chargers in Week 10.

Analysis: The 49ers rank fourth with 29 sacks and fourth with 18.1 points allowed per game this season, and they should be considered an elite option for the rest of the season. It's unclear if QB Kyler Murray (hamstring) or QB Colt McCoy (knee) will start for the Cardinals, but regardless, Murray could be a bit hobbled if he plays and McCoy lowers this team's ceiling immensely. The 49ers had a high floor even if Murray was 100 percent, so fantasy managers shouldn't hesitate this week.

The 49ers recorded two sacks and no takeaways in the 31-14 win over the Rams in Week 8.

Analysis: The 49ers have given up 18.4 points per game -- the sixth-fewest in the league -- while posting 26 sacks -- the sixth-most in the league. They have high upside and a high floor in nearly every matchup as a result, but facing QB Justin Herbert in Week 10 is always a bit risky. Nevertheless, the Chargers rank 13th this year with a modest 23 points per game. In turn, fantasy managers should feel confident with 49ers D/ST this week, even if it carries more risk than usual.

The 49ers posted two takeaways and a sack in the 44-23 loss to the Chiefs in Week 7.

Analysis: DE Nick Bosa (groin) returned to the lineup, but it wasn't enough against the fierce Chiefs offense. The 49ers didn't allow more than 19 points in a game through the first five weeks, but they have now given up a combined 72 points over the last two weeks. They are set up well to succeed in Week 8 against the Rams, who are coming off a bye. The Rams have averaged just 17.3 points per game (29th) while giving up the second-most turnovers in the league (13). QB Matthew Stafford has also been…read more

The 49ers recorded two sacks in the 28-14 loss to the Falcons in Week 6.

Analysis: The 49ers have one of the league's premier defenses, as it ranks second with just 14.8 points allowed per game and second with 23 sacks. However, it's unclear if DE Nick Bosa (groin) will be ready for the Week 7 matchup against the Chiefs. Even if Bosa can play, the 49ers will be a high-risk option against the league's top-scoring offense (29.8 points per game).

The 49ers recorded six sacks and an interception in the 37-15 win over the Panthers in Week 5.

Analysis: The 49ers haven't allowed more than 19 points in a game this season, and they have given up a league-low 12.2 points per game. They also lead the league in sacks and rank 13th with seven takeaways. While DE Nick Bosa (groin) could miss time, this unit is a must start every week. That includes Week 6 against the Falcons, who have coughed up eight turnovers (eighth) while QB Marcus Mariota has been sacked 12 times.

The 49ers recorded seven sacks, an interception and a fumble recovery in the 24-9 win over the Rams in Week 4.

Analysis: The 49ers defense keeps chugging along, as it has allowed 11.5 points allowed per game (first) while recording 15 sacks (second) and six takeaways (12th). They'll be an elite fantasy option in Week 5 against the Panthers. Through four games, the Panthers have coughed up six turnovers and QB Baker Mayfield has been sacked 11 times. Mayfield looks out of sorts, so the Panthers will likely struggle to move the ball in this matchup.

The 49ers recorded four sacks in the 11-10 loss to the Broncos in Week 3.

Analysis: The 49ers have yet to allow more than 20 points in a game, as they rank third with just 12.7 points allowed per outing. They've also recorded eight sacks and four turnovers. The Rams could be their toughest opponent yet, but there's plenty of upside for 49ers D/ST. After all, the Rams have given up seven turnovers while QB Matthew Stafford has been sacked nine times.

The 49ers recorded three takeaways and two sacks in the 27-7 win over the Seahawks in Week 2.

Analysis: The 49ers haven't faced much competition through the first two weeks, as they've allowed just 26 points against, adding four takeaways and four sacks in the process. The Week 3 matchup against QB Russell Wilson should be tougher, on paper at least. The Broncos have yet to find their rhythm, scoring just 16 points in each of the first two games. Still, Wilson should turn it around soon considering the amount of weapons around him, so the 49ers aren't necessarily a safe pick. But the 49ers D/ST…read more

The 49ers posted two sacks and a takeaway in the 19-10 loss to the Bears in Week 1.

Analysis: We shouldn't read into this performance too much. There was a monsoon, after all. In Week 2, the Seahawks will come to San Francisco after a big win against the Broncos, and they're in danger of a letdown game. QB Geno Smith was sacked twice, and WR DK Metcalf lost a fumble in that contest, and they managed to put up just 17 points anyway. The 49ers' pass rush is menacing, and this unit should have a high floor against the Seahawks' sluggish offense.

S Jimmie Ward (hamstring) will begin the season on injured reserve.

Analysis: Safeties Talanoa Hufanga and George Odum will start the season at safety. The 49ers also added CB Charvarius Ward (groin) to their secondary -- which ranked sixth last year with this offseason with 206.6 yards allowed per game -- this offseason. They could see some regression in that category, though their front seven is mostly the same after a year where they ranked fifth in the league with 48 sacks. Regardless, they'll face the Bears and Seahawks to start the season. They're a top-10 defense…read more

DL Maurice Hurst is expected to miss the 2022 campaign after suffering a torn biceps during the first week of training camp.

Analysis: Hurst appeared in only two games last year while dealing with calf and ankle injuries, and he's now likely to miss all of 2022. As is tradition, San Francisco is dealing with multiple other injuires, with Jason Verrett (knee) on the PUP list while recovering from a torn ACL, and Hassan Ridgeway (quadriceps) and Arik Armstead (knee) picked up injuries early in camp. Nick Bosa will provide a solid floor for the pass rush, but the 49ers D/ST may need some better injury luck in order to be a top…read more

The 49ers ranked third in total defense (310.0 YPG) and tied-fifth in sacks (48) last year and return most of their defense.

Analysis: Injuries once again led to a slow start, but San Francisco rebounded quickly to put together a strong defensive camp. DE Nick Bosa had 15.5 sacks and will continue to lead the charge up front, while LB Fred Warner is a major stabilizer in the middle of the defense. CB Charvarius Ward should bolster the 49ers' pass coverage, which receives a major boost due to the fact the team rarely needs to blitz to pressure the quarterback.

The 49ers allowed 222 yards and seven points during the Week 17 win over the Texans and play the Rams on Sunday.

Analysis: The San Francisco D/ST recorded three sacks and one takeaway while giving up only 3.6 yards per play in a strong performance. Los Angeles had three giveaways last week as QB Matthew Stafford threw his fourth pick-six of the season, as the unit remains a boom-or-bust matchup for fantasy defenses. San Francisco benefitted from one of those pick-sixes in the previous matchup, but it's a risky proposition to rely on that level of playmaking. The 49ers D/ST is a poor option for Week 18.

The 49ers allowed 278 yards and 20 points during the Week 16 OT loss to the Titans and play the Texans on Sunday.

Analysis: The San Francisco D/ST allowed only 4.8 yards per play and had four sacks, but zero takeaway limited the fantasy production of an otherwise solid performance. Week 17 will bring a perfect rebound opportunity against Houston and rookie QB Davis Mills, making the 49ers D/ST one of the top fantasy options for this weekend.

The 49ers allowed 275 yards and 13 points during the Week 15 win over the Falcons and play the Titans on Thursday.

Analysis: The San Francisco D/ST had one takeaway and three sacks while limiting Atlanta to 13 first downs on the day. The undermanned Titans offense could be getting WR A.J. Brown (chest) back from injured reserve Thursday, which would be a big boost for the offense. Regardless, Tennessee has struggled to find much offensive consistency with Derrick Henry (foot) sidelined), and that's unlikely to change this week with Brown fresh off the injury, if available. The 49ers D/ST is a middling option with a…read more

The 49ers allowed 397 yards and 23 points during the Week 14 win over the Bengals and play the Falcons on Sunday.

Analysis: The San Francisco D/ST had five sacks and two takeaways while also holding Cincinnati to 4-for-13 on third-down conversions. The unit has nine sacks and five takeaways across the past two games and has a strong matchup against a Falcons offense that averages 18.8 points. The 49ers D/ST is an above-average option for Week 15.

The 49ers allowed 327 yards and 28 offensive points during the Week 13 loss to the Seahawks and play the Bengals on Sunday.

Analysis: The San Francisco D/ST had four sacks and three takeaways while holding Seattle to 4.8 yards per play, but the Seattle offense still but up 28 points despite scoring only 28 over the previous three contests. The Bengals are coming off a rough game against the Chargers, as they had four giveaways and QB Joe Burrow was sacked six times. The offense is explosive but inconsistent, making the 49ers D/ST a middling option for Week 14 with some risky upside.

The 49ers gave up 323 yards and 26 points during the Week 12 win over the Vikings and play the Seahawks on Sunday.

Analysis: The San Francisco D/ST allowed only 17 first downs as it provided modest fantasy output with one sack and two takeaways. The Seahawks ordinarily would be a tough matchup, but the offense has scuffled mightily since QB Russell Wilson returned from injured reserve (28 points in three games). Even if Seattle's offensive woes continue, it's a low-ceiling matchup since the unit still has strong ball security. The 49ers D/ST is a middling option for Week 13 with a limited ceiling, especially since…read more

The 49ers allowed 200 yards and 10 points during the Week 11 win over the Jaguars and play the Vikings on Sunday.

Analysis: The San Francisco D/ST unsurprisingly had a big day in Jacksonville with three sacks and two takeaways. That's back-to-back productive defensive performances from the 49ers, but a matchup with a strong Minnesota offense awaits this weekend. The Vikings have averaged 30.7 points over the past three games, and QB Kirk Cousins is in the midst of one of the best years of his career with elite weapons RB Dalvin Cook and WRs Justin Jefferson and Adam Thielen. The 49ers D/ST is playing well of late…read more

The 49ers allowed 10 points and 278 yards during the Week 10 win over the Rams and play the Jaguars on Sunday.

Analysis: It was a statement game from the 49ers, as coach Kyle Shanahan proved he still has the number of Los Angeles. The San Fran D/ST had two sacks and two takeaways, including a pick-six from S Jimmie Ward. The 49ers have struggled defensively for much of the year but just put forth their best performance and will now face the Jaguars, which are near the bottom of the league in scoring (16.6 PPG) and giveaways (15). The 49ers D/ST certainly isn't a sure thing, but it's a strong option for Week 11…read more

The 49ers allowed 31 points and 437 yards during the Week 9 loss to the Cardinals and play the Rams on Monday.

Analysis: The absence of QB Kyler Murray (ankle) apparently didn't mean much, as backup Colt McCoy was efficient in the passing game and completed 22 of 26 attempts. San Francisco ranks 25th in scoring defense (25.3 PPG), tied-18th in sacks (18) and tied-30th in takeaways (five). The 49ers simply haven't been a strong defensive team this season, and the unit receive much fantasy consideration while going up against an explosive Rams offense.

The 49ers allowed 22 points and 324 yards during the Week 8 win over the Bears and play the Cardinals on Sunday.

Analysis: The San Francisco D/ST recorded four sacks and one takeaway, but its inability to slow down QB Justin Fields on the ground (103 rushing yards) prevented a more lucrative fantasy effort. The 49ers are trending down for Week 9, as QB Kyler Murray and the Cardinals are coming off their first loss of the season. The 49ers D/ST hasn't been a worthwhile fantasy defense for much of the season, and the poor matchup this weekend leaves it as a fringe option.

The 49ers gave up 30 points and 295 yards during the Week 7 loss to the Colts and play the Bears on Sunday.

Analysis: San Francisco allowed only 4.9 yards per play, but turnovers from the offense helped Indianapolis total four scoring drives of fewer than 50 yards. The 49ers had one sack and two takeaways while giving up only 17 first downs. Rookie QB Justin Fields has struggled since taking over as the starter for Chicago, and the offense had six giveaways against Tampa Bay last week. The 49ers D/ST is one of the top fantasy options for Week 8 given the favorable matchup.

The 49ers come out of the bye week allowing 23.8 PPG and 329.8 YPG and will play the Colts on Sunday Night Football.

Analysis: San Fran went into the bye with a strong effort by limiting QB Kyler Murray and Arizona to 17 points, and the defense should be in a bit better shape after having an extra week to get healthy. QB Carson Wentz has solved most of his severe turnover issues from last year, and Indianapolis is averaging 27.7 points over the past three contests. Still, the Colts offense is hasn't been anything special outside RB Jonathan Taylor, leaving the 49ers D/ST as a solid option for Week 7, especially with so…read more

The 49ers allowed 234 yards and 28 points during the Week 4 loss to the Seahawks and play the Cardinals on Sunday.

Analysis: The Seahawks were unable to consistently move the ball and totaled only 14 first downs while averaging only 4.3 yards per play, but they made those drives count by reaching the end zone. The San Fran D/ST recorded three sacks and zero takeaways, leading to minimal fantasy output. QB Kyler Murray is leading Arizona's high-scoring offense, which leads the league at 35.0 PPG. The 49ers D/ST remains a solid unit overall but isn't a great choice for Week 5 with the Cardinals on a roll.

The 49ers allowed 353 yards and 30 points during the Week 3 loss to the Packers and play the Seahawks on Sunday.

Analysis: The San Francisco D/ST was unable to disrupt QB Aaron Rodgers for most of the day, finishing with one sack and zero takeaways as the future Hall of Famer also delivered a 42-yard drive in 34 seconds to set up a game-winning field goal from Mason Crosby. Meanwhile, Seattle is coming off an ugly showing in Minnesota when it managed only 17 points, all of which were scored during the first half. The 49ers had trouble covering WR Davante Adams last week, and WRs DK Metcalf and Tyler Lockett present…read more

The 49ers allowed 328 yards and 11 points during the Week 2 win over the Eagles and play the Packers on Sunday.

Analysis: San Francisco kept Philadelphia out of the end zone until four minutes were left in the contest and also allowed only 18 first downs. There were no turnovers by either team, but the 49ers did manage a pair of sacks. It's not an overly exciting performance from a fantasy perspective, but it's a great sign to see San Francisco shutting down quality offense. QB Aaron Rodgers and the Packers present similar issues in Week 3, which will limit the ceiling for the 49ers D/ST even with another solid…read more

The 49ers gave up 430 yards and 33 points during the Week 1 win over the Lions and play the Eagles on Sunday.

Analysis: San Francisco took a 31-10 lead into halftime, and Detroit staged a valiant comeback effort that came up short. LB Dre Greenlaw produced the 49ers' lone takeaway on the day with a pick-six, and the defense also registered three sacks. Overall it was a strong performance from the defense despite the Lions' second-half surge. QB Jalen Hurts looked fantastic Week 1 for the Eagles, and young WRs DeVonta Smith and Jalen Reagor both flashed their potential. The 49ers defensive talent will keep in on…read more

Safety Jaquiski Tartt (toe) was activated from the PUP list in late August and should start in San Francisco's season opener against Detroit on Sunday.

Analysis: The 49ers had terrible injury luck in 2020 and are poised for a bounce-back 2021 campaign as a result. They'll have a prime opportunity to start strong Sunday, as the Lions no longer have QB Matthew Stafford or top WR Kenny Golladay. QB Jared Goff will have his work cut out for him, as there's not much to offer as offensive weapons behind RB D'Andre Swift and TE T.J. Hockenson. The San Francisco D/ST is one of the top options for Week 1 against the new-look Lions.

The 49ers defense is managing numerous injuries in training camp, and S Jaquiski Tartt (toe) is on the PUP list.

Analysis: Tartt is the only significant contributor not on the active roster, so there's a chance the other players are only dealing with minor injuries. DE Nick Bosa (knee) remains on track to be ready for Week 1 as he returns from a torn ACL. Injuries are always a preseason concern, but especially for San Francisco after enduring an injury-riddled campaign in 2020. Thankfully there's still over three weeks for the unit to get healthy before Week 1.

DT Javon Kinlaw is easing into 49ers' training camp due to knee swelling.

Analysis: Kinlaw underwent minor knee surgery in January in is still experiencing some swelling. DEs Dee Ford (neck) and Nick Bosa (knee) are returning from their own injuries but are expected to be ready for the start of the regular season. San Francisco is coming off a season in which it was decimated by injuries, so it's even more important the unit is able to start the campaign fully healthy. Assuming the group has better injury luck in 2021, it should be one of the better defenses in the league.

DE Nick Bosa (knee) is expected to be ready for the start of training camp.

Analysis:

The 49ers allowed 12 points and 350 yards during the Week 16 win over the Cardinals and play the Seahawks on Sunday.

Analysis:

San Francisco surrendered 291 yards and 41 points during the Week 15 loss to Dallas and plays Arizona on Saturday.

Analysis:

San Francisco gave up 193 yards and nine offensive points during the Week 14 loss to Washington and play Dallas on Sunday.

Analysis:

The 49ers gave up 449 yards and 34 points during the Week 13 loss to the Bills and play Washington on Sunday.

Analysis:

The 49ers gave up 308 yards and 13 offensive points during the Week 12 win over the Rams and play the Bills on Monday.

Analysis:

The 49ers come out of their bye week ranked seventh in total defense (315.9 YPG) and 11th in scoring (23.4 PPG) as they head into Sunday's game against the Rams.

Analysis:

The 49ers gave up 405 yards and 34 points during the Week 9 loss to the Packers and play the Saints on Sunday.

Analysis: QB Aaron Rodgers had a stellar day and averaged 9.8 yards per attempt, while WR Davante Adams had 10 catches for 173 yards and a score. Unfortunately for San Francisco, things don't get much better in Week 10 as it heads to New Orleans, which just put down a beatdown on Tampa Bay's strong defense. The 49ers D/ST is once again a poor option this week while going up against QB Drew Brees and a Saints offense that excels in ball security (seven giveaways) and pass protection (10 sacks allowed).

The 49ers gave up 350 yards and 37 points during the Week 8 loss to the Seahawks and play the Packers on Thursday.

Analysis: San Fran had zero answer for WR DK Metcalf, as he had 12 receptions for 161 yards and two touchdowns. WR Davante Adams presents similar matchup problems in Week 9, as he has 20 catches for 249 yards and five touchdowns in the past two games. The Packers have only three giveaways and nine sacks allowed through seven games, so there may not be significant playmaking chances. The 49ers D/ST faces a tough matchup for the second consecutive week.

The 49ers allowed 241 yards and six points during the Week 7 win over the Patriots and play the Seahawks on Sunday.

Analysis: San Francisco entered the contest with only six takeaways all season, but it had four interceptions off Cam Newton and Jarrett Stidham while holding New England to a pair of field goals. Russell Wilson is coming off a similar performance against the Cardinals as he threw three picks, but a repeat performance shouldn't be expected. The Seahawks has the top offense in the league in scoring (33.8 PPG) and yardage (425.2 YPG) and has yet to score fewer than 27 points in a game this season. The…read more

The 49ers allowed 311 yards and 16 points during the Week 6 win over the Rams and play the Patriots on Sunday.

Analysis: It was a solid defensive performance from San Francisco, yet it provided little fantasy production with one takeaway and zero sacks. The Patriots continue to lean on their run game (167.2 YPG and 5.1 YPC), and QB Cam Newton being farther removed from his absence due to COVID-19 should help after the offense was sluggish last week. The 49ers D/ST ranks in the bottom half of the league with six takeaways and 10 sacks, making it a middling fantasy matchup for Week 7. However, starters Jaquiski…read more

The 49ers surrendered 43 points and 436 yards during the Week 5 loss to the Dolphins and play the Rams on Sunday.

Analysis: It was an absolute thrashing from Miami as QB Ryan Fitzpatrick averaged 12.5 yards per attempt, and it could have been even worse as it settled for five field goals. San Francisco's injury issues remain a significant problem going forward, and the matchup against a more-talented Rams offense limits the outlook for the 49ers D/ST in Week 6.

The 49ers allowed 18 offensive points and 267 yards during the 25-20 loss to the Eagles and play the Dolphins on Sunday.

Analysis: San Francisco had one takeaway, three sacks and gave up only 4.5 yards per play, but three giveaways from QB Nick Mullins set up Philly nicely. QB Ryan Fitzpatrick and the Dolphins are averaging 23.3 points and 347 yards and have protected the passer well (six sacks allowed) through four games, and they rank middle of the pack with five giveaways. However, Fitzpatrick's propensity for turnovers is well known, and he threw a pair of interceptions last week. The 49ers D/ST is still pretty banged…read more

The 49ers held the Giants to 231 yards and nine points during the Week 3 victory and play the Eagles on Sunday.

Analysis: San Francisco had zero issues against New York despite the massive injury concerns, totaling two sacks and three takeaways. QB Carson Wentz is off to an atrocious start in 2020 with two interceptions in each game plus three total fumbles (one loss), and he's also been sacked 11 times. Wentz and the Philly offense very well could turn things around this season, but as of now it makes for an attractive fantasy matchup for the 49ers D/ST, even with the injuries.

DLs Nick Bosa and Solomon Thomas suffered torn ACLs in Week 2 and are out for the season heading into Sunday's game against the Giants.

Analysis: It was a costly win against the Jets in the second game of the season, as DE Dee Ford (back) is also expected to miss at least one game. The matchup with the Giants in Week 3 remains an attractive option, but the 49ers are missing most of the teeth from a dominant front four while also missing their top corner Richard Sherman (calf). San Francisco has enough talent to remain on the fantasy radar in New York this week -- especially with RB Saquon Barkley (knee) sidelined -- but it's propensity…read more

CB Richard Sherman has an apparent leg injury and may be placed on injured reserve ahead of the Week 1 matchup with the Jets

Analysis: It would be a significant loss for the 49ers, who surrendered 24 points and 404 yards in the Week 1 loss to the Cardinals while recording one takeaway and two sacks. QB Kyler Murray had 230 passing yards and 91 rushing yards with two total touchdowns, but they won't be facing a dual-threat option of that caliber most weeks. A matchup with the Jets is a welcome sight, as New York managed only 17 points with two giveaways and three sacks allowed in the season opener. It's worth keeping an eye on…read more

The 49ers will play the Cardinals in the season opener Sunday afternoon.

Analysis: It's a solid matchup on paper for San Fran and its potent pass rush, as Arizona ranked tied-26th in sacks allowed (50) last season, and much of the offensive line is familiar faces. However, the addition of DeAndre Hopkins to the receiving corps completely changes the complexion of the offense, providing QB Kyler Murray a top-tier weapon for his second season. The 49ers D/ST is a high-floor option based on their success last season, but the Cardinals took good care of the ball (tied-ninth with…read more

The 49ers ranked second in total defense (281.8 YPG), eighth in scoring (19.4 PPG), tied-fifth in sacks (48) and sixth in takeaways (27) last season.

Analysis: The departure of DeForest Buckner can't be overstated, but if there's one team that can manage the talent loss, it's the 49ers. First-round pick DT Javon Kinlaw should step into the starting role, and the rest of the defense remains intact. Nick Bosa, Dee Ford and Arik Armstead should again lead one of the most potent pass rushes in the league.

The 49ers allowed 395 yards and 31 points to the Rams in Week 16 and play the Seahawks on Sunday.

Analysis: San Francisco struggled to stop the Rams for most of the contest with zero sacks and one takeaway, but that one takeaway proved pivotal as Fred Warner returned an interception for a touchdown. The 49ers still rank second in total defense (277.4 YPG), eighth in scoring (19.3 PPG), tied-fifth in takeaways (27) and fifth in sacks (47), but they're allowing 35.3 points in the last three games. QB Russell Wilson remains one of the most efficient signal callers in the league, but the Seahawks are…read more

The 49ers allowed 290 yards during the Week 15, 29-22 loss to the Falcons and play the Rams on Saturday.

Analysis: The Falcons scored on touchdown on the final play as the 49ers attempted a last-ditch lateral, and they provided little value with only two sacks and one takeaway. The return of CB Richard Sherman (hamstring) should help this weekend,as San Fran attempts to replicate its previous performance against Los Angeles after it gave up only 157 yards. The 49ers D/ST should be a solid option once again in Week 16.

The 49ers allowed 465 yards during the Week 14, 48-46 win over the Saints and play the Falcons on Sunday.

Analysis: The San Fran defense had its first major dud of the season, as it had only one sack and zero takeaways. Week 15 presents a much more friendly matchup, as the Falcons rank tied-21st in giveaways (21) and tied-24th in sacks allowed (41). Atlanta still has some quality weapons -- assuming Devonta Freeman (knee) and Julio Jones (shoulder) are available to play -- but there's no reason to suggest the San Francisco D/ST won't return to its more typical 2019 form as a solid fantasy option.

The 49ers allowed 283 yards during the Week 13, 20-17 loss to the Ravens and play the Saints on Sunday.

Analysis: San Francisco put forth a fantastic defensive effort, giving up only 4.6 yards per play and stifling the passing game, but QB Lamar Jackson still did just enough on the ground (16 carries for 101 yards and one TD) to help secure the win for Baltimore. Howver, only one sack and one takeway meant limited fantasy output. Week 14 presents another tough challenge versus New Orleans, again on the road. The 49ers D/ST has been good enough to trust against essentially all comers in 2019, but it's still…read more

The 49ers held the Packers to 198 yards and eight points in Week 12 and will play the Ravens on Sunday.

Analysis: San Francisco had zero problem shutting down QB Aaron Rodgers, as he was sacked five times and averaged a paltry 3.2 yards per pass. Week 13 brings forward a bigger challenge in QB Lamar Jackson, who's led Baltimore to 40-plus points in three straight games. The 49ers D/ST has proven it's worth standing by week in and week out regardless of matchup, but the Ravens are currently the hottest offense in the league and feature the MVP frontrunner. It's a solid idea to at least check out available…read more

The 49ers gave up 266 yards and 26 points to the Cardinals in Week 11 and will play the Packers on Sunday Night Football.

Analysis: San Fran had trouble stopping QB Kyler Murray on the ground (eight carries for 67 yards and one TD), but otherwise was able to hold Arizona's offense in check. The 49ers continue to be one of the top defenses in the league but the Packers represent a tough matchup. The San Francisco D/ST is a safe bet to get at least a couple sacks, but QB Aaron Rodgers' and Green Bay's ball security (only seven giveaways) keeps it a middling matchup, at best.

The 49ers gave up 336 yards in Monday's 27-24 overtime loss to the Seahawks and will play the Cardinals in Week 11.

Analysis: San Fran racked up five sacks and four takeaways, including a fumble return for a touchdown. The 49ers still rank second in the league in total defense (251.6 YPG), scoring (14.3 PPG) and sacks (35), while also being third in takeaways (20). Rookie QB Kyler Murray and the Cardinals are tied for the league lead in giveaways (six), but the 49ers remain a quality fantasy option in Week 11.